Synopsis: Killy is a man in a neo-futuristic world populated with humans, and humanoid like creatures living in huge mechanical towers. Killy is in search of humans who have Net Terminal Genes, and he has a mysteriously badass gun that he has no idea how he got it. Also, in this world, there is an entity/force called The Authority, which controls robots and is feared by humans.
BLAME! is classified as science fiction, but it could be almost any genre because the reader is given little to grasp. Most of this manga consists of action shots. Plot progression, character development, and even spoken words take a second seat to constant barrages of confusing scenes of violence and meandering views of the giant towers. The premise is confusing enough, but the added element of leaving most things a mystery (even by the end of the second book) gets wearisome after you've gone through so many pages of fighting, with no clear reason to care about the fight.
There are several elements similar to The Matrix sequels - the world is humans versus robots, with humans living in prolonged isolation in ridiculously huge mechanical towers. Though the reasoning behind the conflict in The Matrix doesn't exist here, humans aren't used to power the computers/robots. Several items lack any justification, no reason was given for the Killy's relentless searching for Net Terminal Genes, or why he was equipped with this mysterious gun, or why The Authority was ever involved with humans, nor why they've ceased to be involved with humans.
As I previously mentioned, the constant action interspersed with background detail shots muddle the plot, and most of the time, you can't tell who Killy is fighting. The occasional communication (especially in the first book) sheds very little light about what is going on.
Perhaps with all of the violence and action, the OVA anime version of this is much easier to enjoy, but overall it is a violent and confusing view of a desperate and desperately lonely world.